Braco-19 trihydrochloride ( BRACO19 3HCl )

Catalog No. M27756 CAS No. 1177798-88-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Braco-19 trihydrochloride
Note

Research use only, not for human use.
Brief Description

BRACO19 is a telomerase inhibitor. It also stabilizes G-quadruplexes, targeting telomeric G-quadruplexes.
Description

BRACO19 is a telomerase inhibitor. It also stabilizes G-quadruplexes, targeting telomeric G-quadruplexes.(In Vitro):The IC50 for BRACO-19 trihydrochloride (1.0-10 μM) in UXF1138L cells is 2.5 μM, the IC100 is 5 μM. BRACO-19 trihydrochloride (1 μM) dramatically reduces the expression of nuclear hTERT. BRACO-19 trihydrochloride (0-40 μM) dose-dependently decreases the AdV virus growth in eGFP-transinfected HEK 293 cells. BRACO-19 trihydrochloride (0-150 μM) decreases band intensity in an increasing concentration-dependent manner.(In Vivo):In nude mice established UXF1138LX Xenografts, BRACO-19 trihydrochloride (2 mg/kg; i.p.) significantly inhibits tumor growth and shows marked single-agent antitumor activity. some animals in the group shows complete regressions (5 of 12 tumors).
Synonyms

BRACO19 3HCl
Pathway

Others
Target

Other Targets
Recptor

Angiotensin II
Research Area

——
Indication

——

CAS Number

1177798-88-7
Formula Weight

703.2
Molecular Formula

C35H46Cl3N7O2
Purity

>98% (HPLC)
Solubility

——
SMILES

Cl.Cl.Cl.CN(C)c1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)cc1
Chemical Name

——

1.Pei Yu, et al. In vitro metabolism study of saikosaponin d and its derivatives in rat liver microsomes. Xenobiotica. 2017 Jan;47(1):11-19.

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